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A chemo-mechanical constitutive model for transiently cross-linked actin networks and a theoretical assessment of their viscoelastic behaviour
Royal Institute of Technology, (KTH).
Royal Institute of Technology, (KTH).
2013 (English)In: Biomechanics and Modeling in Mechanobiology, ISSN 1617-7959, E-ISSN 1617-7940, Vol. 12, no 2, 373-382 p.Article in journal (Refereed) Published
Abstract [en]

Biological materials can undergo large deformations and also show viscoelastic behaviour. One such material is the network of actin filaments found in biological cells, giving the cell much of its mechanical stiffness. A theory for predicting the relaxation behaviour of actin networks crosslinked with the cross-linker α-actinin is proposed. The constitutive model is based on a continuum approach involving a neo-Hookean material model, modified in terms of concentration of chemically activated cross-links. The chemical model builds on work done by Spiros (Doctoral thesis, University of British Columbia, Vancouver, Canada, 1998) and has been modified to respond to mechanical stress experienced by the network. The deformation is split into a viscous and elastic part, and a thermodynamically motivated rate equation is assigned for the evolution of viscous deformation. The model predictions were evaluated for stress relaxation tests at different levels of strain and found to be in good agreement with experimental results for actin networks cross-linked with α-actinin.

Place, publisher, year, edition, pages
2013. Vol. 12, no 2, 373-382 p.
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:lnu:diva-58914DOI: 10.1007/s10237-012-0406-7OAI: oai:DiVA.org:lnu-58914DiVA: diva2:1055007
Available from: 2016-12-09 Created: 2016-12-09 Last updated: 2016-12-16Bibliographically approved

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