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Changes in Neural Activity Underlying Working Memory after Computerized Cognitive Training in Older Adults
Harvard Med Sch, USA.
Oregon Hlth & Sci Univ, USA.
Harvard Med Sch, USA.
Tufts Univ, USA.
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2016 (English)In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 8, 255Article in journal (Refereed) Published
Abstract [en]

Computerized cognitive training (CCT) may counter the impact of aging on cognition, but both the efficacy and neurocognitive mechanisms underlying CCT remain controversial. In this study, 35 older individuals were randomly assigned to Cogmed adaptive working memory (WM) CCT or an active control CCT, featuring five weeks of five similar to 40 min sessions per week. Before and after the 5-week intervention, event-related potentials were measured while subjects completed a visual n-back task with three levels of demand (0-back, 1-back, 2-back). The anterior P3a served as an index of directing attention and the posterior P3b as an index of categorizationNVM updating. We hypothesized that adaptive CCT would be associated with decreased P3 amplitude at low WM demand and increased P3 amplitude at high WM demand. The adaptive CCT group exhibited a training-related increase in the amplitude of the anterior P3a and posterior P3b in response to target stimuli across n-back tasks, while subjects in the active control CCT group demonstrated a post-training decrease in the anterior P3a. Performance did not differ between groups or sessions. Larger overall P3 amplitudes were strongly associated with better task performance. Increased post-CCT P3 amplitude correlated with improved task performance; this relationship was especially robust at high task load. Our findings suggest that adaptive WM training was associated with increased orienting of attention, as indexed by the P3a, and the enhancement of categorization/WM updating processes, as indexed by the P3b. Increased P3 amplitude was linked to improved performance; however. there was no direct association between adaptive training and improved performance.

Place, publisher, year, edition, pages
2016. Vol. 8, 255
Keyword [en]
computerized cognitive training, working memory, ERPs (Event-Related Potentials), cognitive aging, P3a, P3b, n-back task, P3
National Category
Geriatrics Neurosciences
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-59007DOI: 10.3389/fnagi.2016.00255ISI: 000387185700001OAI: oai:DiVA.org:lnu-59007DiVA: diva2:1056694
Available from: 2016-12-15 Created: 2016-12-14 Last updated: 2016-12-15Bibliographically approved

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Mohammed, Abdul K. H.
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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
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  • Other locale
More languages
Output format
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