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A theoretical assessment of the influence of myosin filament dispersion on smooth muscle contraction
Royal Institute of Technology, (KTH).
2011 (English)In: Presented at ASME Summer Bioengineering Conference, 22-25 June, 2011, ASME Press, 2011, 145-146 p.Conference paper, Abstract (Refereed)
Abstract [en]

A new constitutive model for the biomechanical behavior of smooth muscle tissue is employed to investigate the influence of statistical dispersion in the orientation of myosin filaments. The number of activated cross-bridges between the actin and myosin filaments governs the contractile force generated by the muscle and also the contraction speed. A strain-energy function is used to describe the mechanical behavior of the smooth muscle tissue. The predictions from the constitutive model are compared to histological and isometric tensile test results for smooth muscle tissue from swine carotid artery. In order to be able to predict the active stress at different muscle lengths, a filament dispersion significantly larger than the one observed experimentally was required. Furthermore, a comparison of the predicted active stress for a case of uniaxially oriented myosin filaments and a case of filaments with a dispersion based on the experimental histological data shows that the difference in generated stress is noticeable but limited. Thus, the results suggest that myosin filament dispersion alone cannot explain the increase in active muscle stress with increasing muscle stretch.

Place, publisher, year, edition, pages
ASME Press, 2011. 145-146 p.
National Category
Cell and Molecular Biology Other Materials Engineering
Identifiers
URN: urn:nbn:se:lnu:diva-59483ISBN: 978-0-7918-5458-7 (print)OAI: oai:DiVA.org:lnu-59483DiVA: diva2:1059787
Conference
ASME Summer Bioengineering Conference, 22-25 June, 2011, Farmington, Pennsylvania, USA
Available from: 2016-12-23 Created: 2016-12-23 Last updated: 2017-01-09Bibliographically approved

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Kroon, Martin
Cell and Molecular BiologyOther Materials Engineering

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CiteExportLink to record
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Citation style
  • apa
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  • de-DE
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