The point of departure of this paper is the notion of affect, an intensive and chaotic experience that need to be terminated. For the individual it is necessary to transform the intense experience to feelings or emotions, both social communicable qualities. Transformations are made possible through semiotic systems, like language. It is tempting to understand transformation as transmediation but, as affect is “something” chaotic and thus, by definition impossible to frame in a semiotic system, no mediation is at hand in the first place (which is required for a transmediation). When individuals are mediating affective experiences through transformations they gain knowledge, as mediation according Säljö is a process of learning. These mediations can either connect to already established articulations or be renegotiations of these. Focus in this paper will be on the transformations of the mediated affects. Mediations of mental distress (understood here as affect) will be used as a case in point, mediations that can take shape of bodily configurations, for instance self-injury. Representations of these mediations transmediated as, for instance photos, drawings or poems are often published on internet by those experiencing mental distress. Arguably they can trough these transmediations and publications obtain additional knowledge of their experience. The purpose with this paper is to discuss how different modes, media and mediums, with their particular capacities, can make various kind of knowledge possible for individuals experiencing mental distress. It will suggest a theoretical framework for the articulatory process from affect to transmediation, passing the mediating stage.