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Bayesian analysis of non-thermal structural changes induced by terahertz radiation in protein crystals
University of Gothenburg.
University of Gothenburg.
Chalmers.
University of Gothenburg.
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2016 (English)In: 2016 41ST INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ), IEEE conference proceedings, 2016Conference paper, (Refereed)
Abstract [en]

We have periodically (25ms on - 25ms off) illuminated lysozyme crystals with 0.4 THz radiation and simultaneously monitored their X-ray diffraction intensity in order to study non-thermal structural changes in the protein. In this work we analyze the X-ray scaled and unmerged diffraction intensity observations using a multivariate Bayesian model in order to improve the accuracy of the intensity estimates. The diffraction intensity pairs of the illuminated and non-illuminated state show a predominantly positive correlation. The correlation decreases with increasing resolution suggesting that finer slicing and faster sampling of the rocking curve may further improve the accuracy and effect size of structure factor amplitude differences, making the interpretation of structural changes more straightforward. The improved analysis retains the most important structural features described previously (in helix 3) and provide addition details about the B-factor changes close to the substrate binding site.

Place, publisher, year, edition, pages
IEEE conference proceedings, 2016.
Series
International Conference on Infrared Millimeter and Terahertz Waves, ISSN 2162-2027
National Category
Structural Biology Physical Chemistry
Research subject
Chemistry, Physical Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-60626DOI: 10.1109/IRMMW-THz.2016.7758457ISI: 000391406200119ISBN: 978-1-4673-8485-8 (print)OAI: oai:DiVA.org:lnu-60626DiVA: diva2:1073322
Conference
41st International Conference on Infrared, Millimeter, and Terahertz waves (IRMMW-THz), Copenhagen, DENMARK, SEP 25-30 2016
Available from: 2017-02-10 Created: 2017-02-10 Last updated: 2017-02-21Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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