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The alternative complement pathway is dysregulated in patients with chronic heart failure.
Oslo University Hospital, Rikshospitalet, Norway ; University of Oslo, Norway.
Oslo University Hospital, Rikshospitalet, Norway ; University of Oslo, Norway.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Oslo University Hospital, Rikshospitalet, Norway ; University of Oslo, Norway. (Linnaeus Ctr Biomat Chem)ORCID iD: 0000-0002-7192-5794
University of Oslo, Norway.
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 1-10 p., 42532Article in journal (Refereed) Published
Abstract [en]

The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured in plasma from 188 HF patients and 67 age- and sex- matched healthy controls by enzyme immunoassay. Our main findings were: (i) Compared to controls, patients with HF had significantly increased levels of factor D and TCC, and decreased levels of properdin, particularly patients with advanced clinical disorder (i.e., NYHA functional class IV), (ii) Levels of factor D and properdin in HF patients were correlated with measures of systemic inflammation (i.e., C-reactive protein), neurohormonal deterioration (i.e., Nt-proBNP), cardiac function, and deteriorated diastolic function, (iii) Low levels of factor H and properdin were associated with adverse outcome in univariate analysis and for factor H, this was also seen in an adjusted model. Our results indicate that dysregulation of circulating components of the alternative pathway explain the increased degree of complement activation and is related to disease severity in HF patients.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 7, 1-10 p., 42532
National Category
Immunology in the medical area Cardiac and Cardiovascular Systems
Research subject
Natural Science, Biomedical Sciences
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URN: urn:nbn:se:lnu:diva-60940DOI: 10.1038/srep42532ISI: 000393866500001PubMedID: 28195242OAI: oai:DiVA.org:lnu-60940DiVA: diva2:1077138
Available from: 2017-02-25 Created: 2017-02-25 Last updated: 2017-11-29Bibliographically approved

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Nilsson, Per H.

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