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Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome
Medical University of Southern Carolina, USA ; University of Denver, USA.
Jewish Home of San Francisco, USA ; University of California, USA.
Medical University of Southern Carolina, USA ; University of Denver, USA.
University of California, USA.
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2016 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, 1-9 p.Article in journal (Refereed) In press
Abstract [en]

INTRODUCTION: Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD neuropathology would be valuable, as non-AD intellectual disabilities of DS and AD dementia overlap clinically. We hypothesized that elevations of amyloid-β (Aβ) peptides and phosphorylated-tau in neuronal exosomes may document preclinical AD.

METHODS: AD neuropathogenic proteins Aβ1-42, P-T181-tau, and P-S396-tau were quantified by enzyme-linked immunosorbent assays in extracts of neuronal exosomes purified from blood of individuals with DS and age-matched controls.

RESULTS: Neuronal exosome levels of Aβ1-42, P-T181-tau, and P-S396-tau were significantly elevated in individuals with DS compared with age-matched controls at all ages beginning in childhood. No significant gender differences were observed.

DISCUSSION: These early increases in Aβ1-42, P-T181-tau, and P-S396-tau in individuals with DS may provide a basis for early intervention as targeted treatments become available.

Place, publisher, year, edition, pages
2016. 1-9 p.
Keyword [en]
Alzheimer's disease, Amyloid-β, Blood biomarkers, Down syndrome, Hyperphosphorylated tau, Intellectual disability, Neuronal exosomes
National Category
Neurosciences
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-61278DOI: 10.1016/j.jalz.2016.08.012PubMedID: 27755974OAI: oai:DiVA.org:lnu-61278DiVA: diva2:1080741
Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-03-20

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Mohammed, Abdul H.
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
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  • de-DE
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