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Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (bio-nano group)ORCID iD: 0000-0002-5889-7792
2016 (English)In: Journal of Muscle Research and Cell Motility, ISSN 0142-4319, E-ISSN 1573-2657, Vol. 37, no 6, p. 181-194Article in journal (Refereed) Published
Abstract [en]

Bridging the gaps between experimental systems on different hierarchical scales is needed to overcome remaining challenges in the understanding of muscle contraction. Here, a mathematical model with well-characterized structural and biochemical actomyosin states is developed to that end. We hypothesize that this model accounts for generation of force and motion from single motor molecules to the large ensembles of muscle. In partial support of this idea, a wide range of contractile phenomena are reproduced without the need to invoke cooperative interactions or ad hoc states/transitions. However, remaining limitations exist, associated with ambiguities in available data for model definition e.g.: (1) the affinity of weakly bound cross-bridges, (2) the characteristics of the cross-bridge elasticity and (3) the exact mechanistic relationship between the force-generating transition and phosphate release in the actomyosin ATPase. Further, the simulated number of attached myosin heads in the in vitro motility assay differs several-fold from duty ratios, (fraction of strongly attached ATPase cycle times) derived in standard analysis. After addressing the mentioned issues the model should be useful in fundamental studies, for engineering of myosin motors as well as for studies of muscle disease and drug development.

Place, publisher, year, edition, pages
2016. Vol. 37, no 6, p. 181-194
National Category
Biophysics
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-61460DOI: 10.1007/s10974-016-9458-0ISI: 000399241700001Scopus ID: 2-s2.0-84995767726OAI: oai:DiVA.org:lnu-61460DiVA, id: diva2:1082878
Available from: 2017-03-19 Created: 2017-03-19 Last updated: 2017-09-22Bibliographically approved

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Månsson, Alf

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