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Using endogenous saccades to characterize fatigue in multiple sclerosis
University of Minho, Portugal ; Association “Todos com a Esclerose Multipla (TEM)”, Portugal.
Association “Todos com a Esclerose Multipla (TEM)”, Portugal ; University of Minho, Portugal.
Association “Todos com a Esclerose Multipla (TEM)”, Portugal.
University of Minho, Portugal.
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2017 (English)In: Multiple Sclerosis and Related Disorders, ISSN 2211-0348, E-ISSN 2211-0356, Vol. 14, 16-22 p.Article in journal (Refereed) Published
Abstract [en]

Purpose

Multiple Sclerosis (MS) is likely to cause dysfunction of neural circuits between brain regions increasing brain working load or a subjective overestimation of such working load leading to fatigue symptoms. The aim of this study was to investigate if saccades can reveal the effect of fatigue in patients with MS.

Methods

Patients diagnosed with MS (EDSS<=3) and age matched controls were recruited. Eye movements were monitored using an infrared eyetracker. Each participant performed 40 trials in an endogenous generated saccade paradigm (valid and invalid trials). The fatigue severity scale (FSS) was used to assess the severity of fatigue. FSS scores were used to define two subgroups, the MS fatigue group (score above normal range) and the MS non-fatigue. Differences between groups were tested using linear mixed models.

Results

Thirty-one MS patients and equal number of controls participated in this study. FSS scores were above the normal range in 11 patients. Differences in saccade latency were found according to group (p<0.001) and trial validity (p=0.023). Differences were 16.9 ms, between MS fatigue and MS non-fatigue, 15.5 ms between MS fatigue and control. The mean difference between valid and invalid trials was 7.5 ms. Differences in saccade peak velocity were found according to group (p<0.001), the difference between MS fatigue and control was 22.3°/s and between MS fatigue and non-fatigue was 12.3°/s. Group was a statistically significant predictor for amplitude (p<0.001). FSS scores were correlated with peak velocity (p=0.028) and amplitude (p=0.019).

Conclusion

Consistent with the initial hypothesis, our study revealed altered saccade latency, peak velocity and amplitude in patients with fatigue symptoms. Eye movement testing can complement the standard inventories when investigating fatigue because they do not share similar limitations. Our findings contribute to the understanding of functional changes induced by MS and might be useful for clinical trials and treatment decisions.

Place, publisher, year, edition, pages
2017. Vol. 14, 16-22 p.
Keyword [en]
Functional assessment, Saccades, Fatigue, Multiple Sclerosis
National Category
Neurology
Research subject
Natural Science, Optometry; Health and Caring Sciences; Natural Science, Medicine
Identifiers
URN: urn:nbn:se:lnu:diva-61912DOI: 10.1016/j.msard.2017.01.014ISI: 000405049900006PubMedID: 28619425OAI: oai:DiVA.org:lnu-61912DiVA: diva2:1085087
Available from: 2017-03-28 Created: 2017-03-28 Last updated: 2017-07-28Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2018-05-01 08:00
Available from 2018-05-01 08:00

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Macedo, António Filipe
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CiteExportLink to record
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