In this article, we briefly identify three main challenges/issues that should be taken into consideration in the institutionalization of entrepreneurship research: (1) recognizing the complexity of the phenomenon under study; (2) producing interesting, relevant and useful research results for all stakeholders; and (3) developing a critical posture in research. Following the discussion of these challenges/issues we introduce the five contributions to the Special Issue that, in different ways, problematize and challenge mainstream research and approaches. These articles use ‘dissensus discourses’, apply critical, ideological and paradigmatic stances and in some cases underline the importance of contextual factors.