lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evolution of antigenic diversity in the tick-transmitted bacterium Borrelia afzelii: a role for host specialization?
Lund University.
Lund University ; Lab Med Clin Genet & Biobank, Lund.
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Lund University. (Ctr Ecol & Evolut Microbial Model Syst, EEMiS)
Lund University.
Show others and affiliations
2017 (English)In: Journal of Evolutionary Biology, ISSN 1010-061X, E-ISSN 1420-9101, Vol. 30, no 5, 1034-1041 p.Article in journal (Refereed) Published
Abstract [en]

Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host-pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence and infection intensity of ospC strains in naturally infected wild mammals (rodents and shrews) by 454 amplicon sequencing in combination with qPCR. Neither prevalence nor infection intensity of specific ospC strains varied in a species-specific manner (i.e. there were no significant ospCxhost species interactions). Rankings of ospC prevalences were strongly positively correlated across host species. Rankings of ospC infection intensities were correlated more weakly, but only in one case significantly <1. ospC prevalences in the studied mammals were similar to those in ticks sampled at the study site, indicating that we did not miss any mammal species that are important hosts for specific ospC strains. Based on this, we conclude that there is at best limited host specialization in B.afzelii and that other processes are likely the main drivers of ospC diversity.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2017. Vol. 30, no 5, 1034-1041 p.
Keyword [en]
antigenic diversity, ecological specialization, Lyme borreliosis
National Category
Ecology Microbiology
Research subject
Ecology, Zoonotic Ecology
Identifiers
URN: urn:nbn:se:lnu:diva-66999DOI: 10.1111/jeb.13075ISI: 000400783800015PubMedID: 28345277OAI: oai:DiVA.org:lnu-66999DiVA: diva2:1127821
Available from: 2017-07-19 Created: 2017-07-19 Last updated: 2017-07-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersson, Martin O.
By organisation
Department of Biology and Environmental Science
In the same journal
Journal of Evolutionary Biology
EcologyMicrobiology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf