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Monoprotected L-Amino Acid (L-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp(2))-H Bonds by Iridium(III) Catalysis
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Ctr Biomat Chem)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (Ctr Biomat Chem)ORCID iD: 0000-0002-0407-6542
2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 29, 7031-7036 p.Article in journal (Refereed) Published
Abstract [en]

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected L-amino acid (L-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/L-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp(2))-H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2017. Vol. 23, no 29, 7031-7036 p.
Keyword [en]
anilides, C-H activation, halogenation, iridium, L-MPAA
National Category
Chemical Sciences
Research subject
Natural Science, Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-66986DOI: 10.1002/chem.201700280ISI: 000401992100016PubMedID: 28221698OAI: oai:DiVA.org:lnu-66986DiVA: diva2:1127872
Available from: 2017-07-20 Created: 2017-07-20 Last updated: 2017-07-20Bibliographically approved

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Kathiravan, SuppanNicholls, Ian A.
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CiteExportLink to record
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Citation style
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