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The link between morphology and complement in ocular disease
Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2017 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, no 89, 84-99 p.Article in journal, Editorial material (Refereed) Published
Abstract [en]

The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases. The potential benefits of complement inhibition in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica are abundant, as are those of further research to improve our understanding of complement-mediated injury in these diseases.

Place, publisher, year, edition, pages
2017. no 89, 84-99 p.
Keyword [en]
Age-related macular degeneration; Complement; Eye; Glaucoma; Morphology; Neuromyelitis optica; Uveitis
National Category
Natural Sciences
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-67981OAI: oai:DiVA.org:lnu-67981DiVA: diva2:1141706
Available from: 2017-09-15 Created: 2017-09-15 Last updated: 2017-09-15

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  • apa
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