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Sarcomere Stiffness during Stretching and Shortening of Rigor Skeletal Myofibrils
McGill Univ, Canada;McGill Univ, Canada.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. McGill Univ, Canada;Karolinska Institutet.ORCID iD: 0000-0003-2819-3046
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-5889-7792
McGill Univ, Canada.
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2017 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 113, no 12, p. 2768-2776Article in journal (Refereed) Published
Abstract [en]

In this study, we measured the stiffness of skeletal muscle myofibrils in rigor. Using a custom-built atomic force microscope, myofibrils were first placed in a rigor state then stretched and shortened at different displacements (0.1-0.3 mu m per sarcomere) and nominal speeds (0.4 and 0.8 mu m/s). During stretching, the myofibril stiffness was independent of both displacement and speed (average of 987 nN/mu m). During shortening, the myofibril stiffness was independent of displacement, but dependent on speed (1234 nN/mu m at 0.4 mu m/s; 1106 nN/mu m at 0.8 mu m/s). Furthermore, the myofibril stiffness during shortening was greater than that during stretching and the difference depended on speed (31 % at 0.4 mu m/s; 8% at 0.8 mu m/s). The results suggest that the myofibrils exhibit nonlinear viscoelastic properties that may be derived from myofibril filaments, similar to what has been observed in muscle fibers.

Place, publisher, year, edition, pages
2017. Vol. 113, no 12, p. 2768-2776
National Category
Biophysics
Research subject
Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-69765DOI: 10.1016/j.bpj.2017.10.007ISI: 000418502800018OAI: oai:DiVA.org:lnu-69765DiVA, id: diva2:1173510
Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-01-12Bibliographically approved

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Persson, MalinMånsson, Alf

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