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Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study
Univ Bologna, Italy.
Univ Autonoma Madrid, Spain;Inst Salud Carlos III, Spain;IMDEA, Spain;CEI UAM CSIC, Spain.
Univ Ghent, Belgium.
Univ Lille Nord France, France.
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2018 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 253, p. 167-173Article in journal (Refereed) Published
Abstract [en]

Background: Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods: This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (<1%), intermediate (1% to <5%), high (>5% to <10%) or very high (>10%). Results: Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95% CI: 1.34-1.44]) and all subgroups (using diuretics: 1.32 [1.24-1.40]; not using diuretics: 1.46 [1.39-1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m(2): 1.30 [1.22-1.38]; eGFR >= 60 ml/min/1.73 m(2): 1.44 [1.38-1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions: Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease. (c) 2017 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 253, p. 167-173
Keywords [en]
Serum uric acid, Cardiovascular risk, European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA), Systematic COronary Risk Evaluation (SCORE), Systematic COronary Risk Evaluation algorithm including high-density lipoprotein cholesterol (SCORE-HDL)
National Category
Nursing Cardiac and Cardiovascular Systems
Research subject
Health and Caring Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-70244DOI: 10.1016/j.ijcard.2017.10.045ISI: 000419221500034PubMedID: 29306459OAI: oai:DiVA.org:lnu-70244DiVA, id: diva2:1178561
Available from: 2018-01-30 Created: 2018-01-30 Last updated: 2018-01-30Bibliographically approved

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Perk, Joep

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