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Altered Cytokine and BDNF Levels in Autism Spectrum Disorder
Univ Roma La Sapienza, Italy.
Sapienza Univ, Italy.
Univ Roma La Sapienza, Italy.
Univ Roma La Sapienza, Italy.
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2013 (English)In: Neurotoxicity research, ISSN 1029-8428, E-ISSN 1476-3524, Vol. 24, no 4, p. 491-501Article in journal (Refereed) Published
Abstract [en]

The contribution of neuroimmune functioning and brain-derived neurotrophic factor (BDNF) to functional dysregulation in autism spectrum disorder was assessed in 29 patients under treatment in two specialized centers of Basilicata (Chiaromonte and Matera), Southern Italy, through analysis of serum levels of cytokines and BDNF. Elevated levels of the pro-inflammatory cytokine, including interleukin-1, interleukin-6, interleukin-12, interleukin-23, tumor necrosis factor-alpha and BDNF were observed, regardless of age and gender. Comparisons were made with age-and gender-related healthy controls. The present findings reinforce current notions regarding immunoexcitotoxic mechanisms contributing to the pathophysiology of autistic disorder.

Place, publisher, year, edition, pages
Springer, 2013. Vol. 24, no 4, p. 491-501
Keywords [en]
Autism, Immune system, Cytokines, Handicap, Immunoexcitotoxicity
National Category
Neurosciences Psychology
Research subject
Social Sciences, Psychology
Identifiers
URN: urn:nbn:se:lnu:diva-70987DOI: 10.1007/s12640-013-9393-4ISI: 000328145300004PubMedID: 23604965OAI: oai:DiVA.org:lnu-70987DiVA, id: diva2:1183729
Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-02-19Bibliographically approved

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Archer, Trevor

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