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The link between morphology and complement in ocular disease
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (Linnaeus Ctr Biomat Chem)ORCID iD: 0000-0001-7888-1571
Uppsala University.ORCID iD: 0000-0003-0057-2730
2017 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 89, p. 84-99Article, review/survey (Refereed) Published
Abstract [en]

The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword that is essential for protection but may also become harmful and contribute to eye pathology. Here, we review the evidence for the involvement of complement system dysregulation in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica, highlighting the relationship between morphogical changes and complement system protein expression and regulation in these diseases. The potential benefits of complement inhibition in age-related macular degeneration, glaucoma, uveitis, and neuromyelitis optica are abundant, as are those of further research to improve our understanding of complement-mediated injury in these diseases.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 89, p. 84-99
Keywords [en]
Complement, Eye, Morphology, Age-related macular degeneration, Glaucoma, Uveitis, Neuromyelitis optica
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-71382DOI: 10.1016/j.molimm.2017.05.028ISI: 000410014500010PubMedID: 28622910OAI: oai:DiVA.org:lnu-71382DiVA, id: diva2:1187559
Conference
16th European Meeting on Complement in Human Disease (EMCHD), SEP 08-12, 2017, Copenhagen, DENMARK
Available from: 2018-03-05 Created: 2018-03-05 Last updated: 2018-03-05Bibliographically approved

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Mohlin, CamillaSandholm, KerstinNilsson Ekdahl, Kristina

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Mohlin, CamillaSandholm, KerstinNilsson Ekdahl, KristinaNilsson, Bo
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