This chapter focuses on the important role of the European Commission as a driving engine and agenda-setter for entrepreneurship. In line with previous research which has shown how crises can be opportunities for change, examples of how the Commission has acted as a political entrepreneur are presented. In a time of long-term economic crisis, the Commission has approached entrepreneurship and the promotion of entrepreneurial activities through different initiatives, such as the Small Business Act for Europe and the Entrepreneurship 2020 Action Plan. Entrepreneurship is viewed as necessary to create companies and job opportunities, to identify and enter new markets and to promote new know-how and skills. An important part of promoting entrepreneurship is introducing entrepreneurship into all areas of education. Education as a political concern is linked to EU policy in relation to its growth policy ambitions and is influenced by the economic motives underpinning entrepreneurship education. The economic crises of 2008 have served as a “window of opportunity” for making changes possible.