lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Blir behandlingen av reumatoid artrit mer effektiv med tillägg av infliximab och är biosimilaren CT-P13 lika effektiv?
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2018 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Rheumatoid arthritis (RA) is a chronic joint disease which mechanism of action is unknown. The immune mechanism initiates an inflammatory process that mainly affects the joints, which can lead to cartilage and bone damage but also to some generalized symptoms such as fatigue and inflammatory anemia. At present, RA is primarily treated with methotrexate (MTX) as monotherapy. Studies in the field indicate that MTX in combination with infliximab, a monoclonal antibody, is more effective in treating RA than MTX treatment alone. Most likely, infliximab is not used as first-hand therapy since the reference product Remicade® is very expensive. In 2015 the patent for Remicade® expired and there are now cheaper biosimilars available that have been approved for the same indication as Remicade®.

The aim of this study was to investigate whether MTX in combination with infliximab is more effective than MTX alone in the treatment of active RA and evaluating whether there is equivalence between the reference product Remicade® and the CT-P13 biosimilar.

The medical and bioscience database PubMed was used to obtain the scientific articles analyzed in this literature study. From PubMed 5 articles were selected for further analysis. The delimitation of the search was: indication RA, MTX, infliximab and biosimilar (CT-P13).

Articles 1-3, based on the outcome variables of the studies indicated that infliximab in combination with MTX is more effective than MTX treatment alone in the treatment of active RA. Articles 4-5 examined equivalence between the reference product for infliximab (RP) and the biosimilar CT-P13 in the treatment of active RA. The analysis and results of articles 4-5 showed that there was a similarity between RP and CT-P13 in treatment of active RA.

Based on this small-scale literature study, treatment with MTX in combination with infliximab seems more beneficial for disease control in active RA than MTX treatment alone. In addition, the biosimilar CT-P13 appears to be equivalent to the reference product Remicade® in the treatment of active RA. Replacement of Remicade® to CT-P13 can mean major savings in healthcare and the therapeutic recommendation for active RA may need to be reviewed as there are now effective, cheaper alternatives.

Place, publisher, year, edition, pages
2018. , p. 35
Keywords [sv]
reumatoid artrit, metotrexat, infliximab, CT-P13
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-72676OAI: oai:DiVA.org:lnu-72676DiVA, id: diva2:1197613
Subject / course
Pharmacy
Educational program
Bachelor of Science Programme in Pharmacy, 180 credits
Supervisors
Examiners
Available from: 2018-04-16 Created: 2018-04-13 Last updated: 2018-04-16Bibliographically approved

Open Access in DiVA

fulltext(836 kB)54 downloads
File information
File name FULLTEXT01.pdfFile size 836 kBChecksum SHA-512
feae6b97d7f9200731e3af0df615ded51213034309c1d14c6537b9570c0722f23c97b41000760332220aa102059ab570d4dbde4df682171b3a89fc2227f94f47
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Brkic, Linda
By organisation
Department of Chemistry and Biomedical Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 54 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 197 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf