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Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa
Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Kalmar County Hospital, Sweden.ORCID iD: 0000-0003-3106-0754
Kalmar County Hospital, Sweden;University Hospital Linköping, Sweden.
Kalmar County Hospital, Sweden.ORCID iD: 0000-0002-0463-8568
2018 (English)In: Eating and Weight Disorders, ISSN 1124-4909, E-ISSN 1590-1262, Vol. 23, no 2, p. 247-254Article in journal (Refereed) Published
Abstract [en]

Purpose Anorexia nervosa (AN) is an eating disorder characterized by low fat mass complicated by osteoporosis. The role of circulating vitamin D in the development of bone loss in AN is unclear. Fat mass is known to be inversely associated with vitamin D levels measured as serum levels of total, protein-bound 25-hydroxyvitamin D, but the importance of directly measured, free levels of 25(OH)D has not been determined in AN. The aim of this study was to investigate vitamin D status, as assessed by serum concentrations of total and free serum 25(OH)D in patients with AN and healthy controls. Methods In female AN patients (n = 20), and healthy female controls (n = 78), total 25(OH)D was measured by LC-MS/MS, and free 25(OH)D with ELISA. In patients with AN bone mineral density (BMD) was determined with DEXA. Results There were no differences between patients and controls in total or free S-25(OH)D levels (80 +/- 31 vs 72 +/- 18 nmol/L, and 6.5 +/- 2.5 vs 5.6 +/- 1.8 pg/ml, respectively), and no association to BMD was found. In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Conclusions The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 23, no 2, p. 247-254
Keywords [en]
Osteoporosis, Vitamin D, Adipose tissue, Anorexia nervosa, Leptin, Parathyroid hormone
National Category
Other Clinical Medicine
Research subject
Natural Science, Medicine
Identifiers
URN: urn:nbn:se:lnu:diva-72685DOI: 10.1007/s40519-017-0392-yISI: 000428082700013PubMedID: 28455680Scopus ID: 2-s2.0-85034639139OAI: oai:DiVA.org:lnu-72685DiVA, id: diva2:1197652
Available from: 2018-04-13 Created: 2018-04-13 Last updated: 2020-10-26Bibliographically approved

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Carlsson, MartinWanby, Pär

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