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Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia
Technion, Israel.
Technion, Israel.
Technion, Israel.
2016 (English)In: Journal of Cell Science, ISSN 0021-9533, E-ISSN 1477-9137, Vol. 129, no 3, p. 543-556Article in journal (Refereed) Published
Abstract [en]

Mitochondria respond to environmental cues and stress conditions. Additionally, the disruption of the mitochondrial network dynamics and its distribution is implicated in a variety of neurodegenerative diseases. Here, we reveal a new function for Myo19 in mitochondrial dynamics and localization during the cellular response to glucose starvation. Ectopically expressed Myo19 localized with mitochondria to the tips of starvation-induced filopodia. Corollary to this, RNA interference (RNAi)-mediated knockdown of Myo19 diminished filopodia formation without evident effects on the mitochondrial network. We analyzed the Myo19–mitochondria interaction, and demonstrated that Myo19 is uniquely anchored to the outer mitochondrial membrane (OMM) through a 30–45-residue motif, indicating that Myo19 is a stably attached OMM molecular motor. Our work reveals a new function for Myo19 in mitochondrial positioning under stress.

Place, publisher, year, edition, pages
2016. Vol. 129, no 3, p. 543-556
National Category
Cell Biology Biochemistry and Molecular Biology Biophysics
Research subject
Natural Science, Cell and Organism Biology
Identifiers
URN: urn:nbn:se:lnu:diva-75921DOI: 10.1242/jcs.175349OAI: oai:DiVA.org:lnu-75921DiVA, id: diva2:1218563
Available from: 2018-06-14 Created: 2018-06-14 Last updated: 2018-06-15Bibliographically approved

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Ušaj, Marko

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