Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarctionShow others and affiliations
2018 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 268, p. 187-192Article in journal (Refereed) Published
Abstract [en]
Background: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1 alpha and IL-1 beta are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling. Methods: Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n=65). Results: IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates. Conclusion: Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI. (C 18 Elsevier B.V. All rights reserved.
Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 268, p. 187-192
Keywords [en]
Inflammation, Cytokine, Interleukin-1, Acute coronary syndromes, Myocardial infarction, Ventricular remodelling
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science, Biomedical Sciences; Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-77369DOI: 10.1016/j.ijcard.2018.05.032ISI: 000439363400045PubMedID: 29853279Scopus ID: 2-s2.0-85047477899OAI: oai:DiVA.org:lnu-77369DiVA, id: diva2:1243305
2018-08-302018-08-302022-03-10Bibliographically approved