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Characterization of avian influenza virus attachment patterns to human and pig tissues
Uppsala University.
Uppsala University.
Univ Copenhagen, Denmark.
Univ Copenhagen, Denmark.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 12215Article in journal (Refereed) Published
Abstract [en]

Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs). Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in their new hosts. Viral adaptions to mammalian hosts include altered receptor preference of host epithelial sialylated oligosaccharides from terminal alpha 2,3-linked sialic acid (SA) towards alpha 2,6-linked SA. However, alpha 2,3-linked SA has been found in human respiratory tract epithelium, and human infections by avian IAVs (AIVs) have been reported. To further explore the attachment properties of AIVs, four AIVs of different subtypes were investigated on human and pig tissues using virus histochemistry. Additionally, glycan array analysis was performed for further characterization of IAVs' receptor structure tropism. Generally, AIV attachment was more abundant to human tissues than to pig tissues. The attachment pattern was very strong to human conjunctiva and upper respiratory tract, but variable to the lower respiratory tract. AIVs mainly attached to alpha 2,3-linked SA, but also to combinations of alpha 2,3-and alpha 2,6-linked SA. The low attachment of these AIV isolates to pig tissues, but high attachment to human tissues, addresses the question whether AIVs in general require passage through pigs to obtain adaptions towards mammalian receptor structures.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 12215
National Category
Microbiology
Research subject
Ecology, Zoonotic Ecology
Identifiers
URN: urn:nbn:se:lnu:diva-77490DOI: 10.1038/s41598-018-29578-1ISI: 000441625500038PubMedID: 30111851Scopus ID: 2-s2.0-85051653603OAI: oai:DiVA.org:lnu-77490DiVA, id: diva2:1244233
Available from: 2018-08-31 Created: 2018-08-31 Last updated: 2019-08-29Bibliographically approved

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Waldenström, Jonas

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