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Stent thrombosis rates the first year and beyond with new- and old-generation drug-eluting stents compared to bare metal stents
Uppsala University.
Västerås County Hospital.
Uppsala University.
Lund University.
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2018 (English)In: Clinical Research in Cardiology, ISSN 1861-0684, E-ISSN 1861-0692, Vol. 107, no 9, p. 816-823Article in journal (Refereed) Published
Abstract [en]

Old-generation drug-eluting coronary stents (o-DES) have despite being safe and effective been associated with an increased propensity of late stent thrombosis (ST). We evaluated ST rates in o-DES, new-generation DES (n-DES) and bare metal stents (BMS) the first year (< 1 year) and beyond 1 year (> 1 year). We evaluated all implantations with BMS, o-DES (Cordis Cypher, Boston Scientific Taxus Libert, and Medtronic Endeavor) and n-DES in the Swedish coronary angiography and angioplasty registry (SCAAR) between 1 January 2007 and 8 January 2014 (n = 207 291). All cases of ST (n = 2 268) until 31 December 2014 were analyzed. The overall risk of ST was lower in both n-DES and o-DES compared with BMS up to 1 year (n-DES versus BMS: adjusted risk ratio (RR) 0.48 (0.41-0.58) and o-DES versus BMS: 0.56 (0.46-0.67), both p < 0.001). From 1 year after stent implantation and onward, the risk for ST was higher in o-DES compared with BMS [adjusted RR, 1.82 (1.47-2.25], p < 0.001). N-DES were associated with similar low ST rates as BMS from 1 year and onward [adjusted RR 1.21 (0.94-1.56), p = 0.135]. New-generation DES were associated with lower ST rates in comparison to BMS during the first-year post-stenting. After 1 year, n-DES and BMS were associated with similar ST rates. This study was a retrospective observational study and as such did not require clinical trial database registration.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 107, no 9, p. 816-823
Keywords [en]
Bare metal stents, Drug-eluting stents, Stent thrombosis, Percutaneous coronary intervention
National Category
Nursing
Research subject
Health and Caring Sciences, Nursing
Identifiers
URN: urn:nbn:se:lnu:diva-77726DOI: 10.1007/s00392-018-1252-0ISI: 000442201300010PubMedID: 29667015Scopus ID: 2-s2.0-85045424909OAI: oai:DiVA.org:lnu-77726DiVA, id: diva2:1248073
Available from: 2018-09-13 Created: 2018-09-13 Last updated: 2019-08-29Bibliographically approved

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Carlsson, Jörg

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