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Hierarchical polymeric architectures through molecular imprinting in liquid crystalline environments
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0002-0407-6542
2018 (English)In: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 106, p. 223-231Article in journal (Refereed) Published
Abstract [en]

The use of liquid crystalline (LC) media as sacrificial templates during the polymer synthesis has been explored. The LC-media introduce morphological features into resultant polymers which when used together with molecular imprinting can produce materials with hierarchical architectures. Bupivacaine (1) imprinted co-polymers of 2-hydroxyethylmethacrylate (HEMA) (2a) and 1,4-divinylbenzene (DVB) (3a) were synthesized using photochemical initiation in lyotrophic liquid crystalline phases of AOT (5) in water/p-xylene and Triton X-100 (6) /water systems. SEM studies revealed the impact of the LC-media on polymer morphology, with polymer brush-like structures, with bristles of ≈30 nm diameter. The polymer morphology reflects that of the hexagonal phase of the LC medium. The rebinding characteristics of polymer films were evaluated quartz crystal microbalance (QCM, under FIA conditions). The influence of the presence of imprinting-derived recognition sites in AOT (5) in water/p-xylene polymer film induced brush-like features which provided a 25-fold enhancement of sensor sensitivity. This chemosensor was shown to be selective for the local anesthetic template, bupivacaine, through studies using the structural analogues ropivacaine and mepivacaine.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 106, p. 223-231
Keywords [en]
Bupivacaine, liquid crystalline medium, molecularly imprinted polymer, nanostructured polymer films, piezoelectric sensor, quartz crystal microbalance
National Category
Polymer Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-78287DOI: 10.1016/j.eurpolymj.2018.07.036ISI: 000445993400027Scopus ID: 2-s2.0-85050408593OAI: oai:DiVA.org:lnu-78287DiVA, id: diva2:1255347
Available from: 2018-10-11 Created: 2018-10-11 Last updated: 2019-08-29Bibliographically approved
In thesis
1. New Strategies for Preparing Polymers with Hierarchical Architectures
Open this publication in new window or tab >>New Strategies for Preparing Polymers with Hierarchical Architectures
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The objective of this thesis was to explore novel approaches for controlling morphologies and molecular recognition behaviour of polymers and to use these strategies in conjunction with the molecular imprinting technique in order to either enhance polymer performance in quartz crystal microbalance (QCM) sensor applications, or as an alternative to conventional solvents of polymerization. In Papers I and II, the use of liquid crystalline media in the synthesis of molecularly imprinted polymers was demonstrated. When used in conjunction with the molecular imprinting technique the LC media induced hierarchical material architectures, which provided an enhancement of QCM-sensor sensitivity. The use of a class of novel solvents, so-called “non-ionic deep eutectic solvents (ni-DESs)”, was explored in polymer synthesis, Paper III, and for molecularly imprinted polymer synthesis, Paper IV. The use of these solvents produced polymers with morphological features comparable to those prepared in conventional solvents, and sensitivities towards bupivacaine template were observed. Collectively these results present a new strategy for generating new hierarchical polymer architectures and a new class of solvent for polymer synthesis, which can also be used for molecular imprinting, that can be used as an alternative to conventional and sometimes flammable or toxic polymerization solvents.

Place, publisher, year, edition, pages
Växjö: Linnaeus University Press, 2018. p. 68
Series
Linnaeus University Dissertations ; 329
Keywords
Liquid crystalline media, molecularly imprinted polymers, non-ionic deep eutectic solvents, quartz crystal microbalance
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
urn:nbn:se:lnu:diva-78271 (URN)978-91-88761-96-5 (ISBN)978-91-88761-97-2 (ISBN)
Opponent
Supervisors
Available from: 2018-10-25 Created: 2018-10-11 Last updated: 2018-10-25Bibliographically approved

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Ndizeye, NatachaSuriyanarayanan, SubramanianNicholls, Ian A.

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