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Plasma metabolite profiles in healthy women differ after intervention with supplemental folic acid v. folate-rich foods
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Mansoura Univ, Egypt.ORCID iD: 0000-0003-0550-5828
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-0387-4312
Swedish University of Agricultural Sciences.
2018 (English)In: Journal of Nutritional Science, ISSN 2048-6790, E-ISSN 2048-6790, Vol. 7, p. 1-9, article id e32Article in journal (Refereed) Published
Abstract [en]

Public health authorities recommend all fertile women to increase their folate intake to 400 μg/d by eating folate-rich foods or by taking a folic acid supplement to protect against neural tube defects. In a previous study it was shown that folate-rich foods improved folate blood status as effectively as folic acid supplementation. The aim of the present study was to investigate, using NMR metabolomics, the effects of an intervention with a synthetic folic acid supplement v. native food folate on the profile of plasma metabolites. Healthy women with normal folate status received, in parallel, 500 μg/d synthetic folic acid from a supplement (n 18), 250 μg/d folate from intervention foods (n 19), or no additional folate (0 μg/d) through a portion of apple juice (n 20). The metabolic profile of plasma was measured using 1H-NMR in fasted blood drawn at baseline and after 12 weeks of intervention. Metabolic differences between the groups at baseline and after intervention were assessed using a univariate statistical approach (P ≤ 0·001, Bonferroni-adjusted significance level). At baseline, the groups showed no significant differences in measured metabolite concentrations. After intervention, eight metabolites, of which six (glycine, choline, betaine, formate, histidine and threonine) are related to one-carbon metabolism, were identified as discriminative metabolites. The present study suggests that different folate forms (synthetic v. natural) may affect related one-carbon metabolites differently.

Place, publisher, year, edition, pages
UK: Cambridge University Press, 2018. Vol. 7, p. 1-9, article id e32
Keywords [en]
Folic acid, Folate, Dietary interventions, One-carbon metabolism, Metabolomics
National Category
Nutrition and Dietetics
Research subject
Natural Science, Food Science; Natural Science, Food Science
Identifiers
URN: urn:nbn:se:lnu:diva-79169DOI: 10.1017/jns.2018.22ISI: 000451125400001PubMedID: 30510697OAI: oai:DiVA.org:lnu-79169DiVA, id: diva2:1270151
Available from: 2018-12-12 Created: 2018-12-12 Last updated: 2019-01-24Bibliographically approved

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Hefni, Mohammed E.Witthöft, Cornelia M.

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