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Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke
Kalmar County Hospital.
Kalmar County Hospital.ORCID iD: 0000-0002-0463-8568
Kalmar County Hospital.
Kalmar County Hospital.
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2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 11, article id e0207348Article in journal (Refereed) Published
Abstract [en]

Background The major cause of ischemic stroke is unstable or thrombogenic atherosclerotic plaques. Vascular calcification, a process that appears crucial for plaque stability, shares common features with bone formation. Many bone turnover proteins exhibit metabolic properties, but the evidence is conflicting regarding their possible involvement in vascular disease. Antibodies against sclerostin and dickkopf-1 are currently being evaluated as potential therapy for treating bone disorders. It is important to carefully assess the cardiovascular and metabolic effects of these proteins. The aim of the present study was to explore serum levels of bone turnover markers in patients with acute noncardio-embolic ischemic stroke in comparison with healthy controls. Methods In a cross-sectional study, we compared 48 patients aged. 75 years with noncardio-embolic ischemic stroke and 46 healthy controls. Serum levels of dickkopf-1, sclerostin, osteoprotegerin, osteopontin and osteocalcin were determined by Luminex technique. Results We found clearly increased serum levels of osteoprotegerin, sclerostin, dickkopf-1 and osteopontin in patients with stroke compared with healthy controls. No difference was seen in serum levels of osteocalcin between the two groups. Conclusion Our findings strengthen the hypothesis of bone turnover markers being involved in vascular disease. Whether these proteins can be used as candidate markers for increased stroke risk or prognostic biomarkers remains to be further elucidated.

Place, publisher, year, edition, pages
San Francisco: Public Library of Science (PLoS) , 2018. Vol. 13, no 11, article id e0207348
National Category
Cardiac and Cardiovascular Systems
Research subject
Natural Science, Medicine
Identifiers
URN: urn:nbn:se:lnu:diva-79611DOI: 10.1371/journal.pone.0207348ISI: 000451763800027PubMedID: 30496210Scopus ID: 2-s2.0-85057492323OAI: oai:DiVA.org:lnu-79611DiVA, id: diva2:1280450
Available from: 2019-01-18 Created: 2019-01-18 Last updated: 2019-08-29Bibliographically approved

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Wanby, PärCarlsson, Martin

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