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Adherence to risk management guidelines for drugs which cause vitamin D deficiency – big data from the Swedish health system
Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Region Kalmar County, Sweden. (DISA ; DISA-IDP)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
County Hospital Kalmar, Sweden;Linköping university, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. County Hospital Kalmar, Sweden.ORCID iD: 0000-0002-0463-8568
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2019 (English)In: Drug, Healthcare and Patient Safety, ISSN 1179-1365, E-ISSN 1179-1365, Vol. 11, p. 19-28Article in journal (Refereed) Published
Abstract [en]

Purpose: Several medications are known to cause vitamin D deficiency. The aim of this study is to describe vitamin D testing and supplementation in patients using these “risk medications”, thereby assessing adherence to medical guidelines.Patients and methods: A database with electronic health records for the population in a Swedish County (≈240,000 inhabitants) was screened for patients prescribed the pre-defined “risk medications” during a 2-year period (2014–2015). In total, 12,194 patients were prescribed “risk medications” pertaining to one of the three included pharmaceutical groups. Vitamin D testing and concomitant vitamin D supplementation, including differences between the included pharmaceutical groups, was explored by matching personal identification numbers.Results: Corticosteroids were prescribed to 10,003 of the patients, antiepileptic drugs to 1,101, and drugs mainly reducing vitamin D uptake to 864. Two hundred twenty-six patients were prescribed >1 “risk medication”. Seven hundred eighty-seven patients (6.5%) had been tested during the 2-year period. There were no differences regarding testing frequency between groups. Concomitant supplements were prescribed to 3,911 patients (32.1%). It was more common to be prescribed supplements when treated with corticosteroids. Vitamin D supplementation was more common among tested patients in all three groups. Women were tested and supplemented to a higher extent. The mean vitamin D level was 69 nmol/L. Vitamin D deficiency was found in 24.1% of tested patients, while 41.3% had optimal levels. It was less common to be deficient and more common to have optimal levels among patients prescribed corticosteroids.Conclusion: Adherence to medical guidelines comprising testing and supplementation of patients prescribed drugs causing vitamin D deficiency needs improvement in Sweden.

Place, publisher, year, edition, pages
Dove Medical Press Ltd , 2019. Vol. 11, p. 19-28
National Category
Pharmaceutical Sciences
Research subject
Biomedical Sciences, Pharmacology
Identifiers
URN: urn:nbn:se:lnu:diva-81355DOI: 10.2147/DHPS.S188187ISI: 000462173500001OAI: oai:DiVA.org:lnu-81355DiVA, id: diva2:1299673
Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-11Bibliographically approved

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Nordqvist, OlaWanby, PärCarlsson, Martin

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Nordqvist, OlaLönnbom Svensson, UlrikaWanby, PärCarlsson, Martin
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Department of Medicine and OptometryDepartment of Chemistry and Biomedical Sciences
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