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Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species - Support for the Community Concept
Uppsala University, Sweden.
Uppsala University, Sweden.
Uppsala University, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. (Ctr Ecol & Evolut Microbial Model Syst EEMiS)ORCID iD: 0000-0002-1152-4235
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2019 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 815Article in journal (Refereed) Published
Abstract [en]

Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell receptors and thereby initiate infection. The current study aims at investigating the tissue attachment pattern of a panel of AIVs, comprising H3N2, H6N1, H12N5, and H16N3, to avian trachea and colon tissue samples obtained from host species of different orders. Virus attachment was not restricted to the bird species or order from which the virus was isolated. Instead, extensive virus attachment was observed to several distantly related avian species. In general, more virus attachment and receptor expression were observed in trachea than in colon samples. Additionally, a human seasonal H3N2 virus was studied. Unlike the studied AIVs, this virus mainly attached to tracheae from Charadriiformes and a very limited set of avian cola. In conclusion, the reported results highlight the importance of AIV attachment to trachea in many avian species. Finally, the importance of chickens and mallards in AIVs dynamics was illustrated by the abundant AIV attachment observed.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, article id 815
Keywords [en]
virus histochemistry, lectin staining, pattern of virus attachment, avian influenza, birds
National Category
Microbiology
Research subject
Biomedical Sciences, Virology
Identifiers
URN: urn:nbn:se:lnu:diva-82412DOI: 10.3389/fmicb.2019.00815ISI: 000464963200002Scopus ID: 2-s2.0-85068167841OAI: oai:DiVA.org:lnu-82412DiVA, id: diva2:1313360
Available from: 2019-05-03 Created: 2019-05-03 Last updated: 2019-08-29Bibliographically approved

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Waldenström, Jonas

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