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Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models
Uppsala University, Sweden.
Univ Tokyo, Japan.
Univ Tokyo, Japan.
Univ Tokyo, Japan.
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2019 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 19, no 5, article id 1800485Article in journal (Refereed) Published
Abstract [en]

Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. The stability of the coatings is investigated in vitro and MPC polymer-coated catheters are tested in vivo by insertion into the external jugular vein of pigs to monitor the catheters' antithrombotic properties. There is no significant activation of platelets or of the coagulation and complement systems in the MPC polymer-coated one, which was superior in hemocompatibility to non-coated matrix surfaces. The protective effect of the MPC polymer coat does not decline after incubation in human plasma for up to 2 weeks. With MPC polymer-coated catheters, it is possible to easily draw blood from pig for 4 days in contrast to the case for non-coated catheters, in which substantial clotting is seen.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2019. Vol. 19, no 5, article id 1800485
Keywords [en]
blood compatibility, blood model systems, coagulation system, complement system, heparin coat, MPC polymer coat
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-86862DOI: 10.1002/mabi.201800485ISI: 000471340300015PubMedID: 30786149Scopus ID: 2-s2.0-85061825928OAI: oai:DiVA.org:lnu-86862DiVA, id: diva2:1337566
Available from: 2019-07-16 Created: 2019-07-16 Last updated: 2019-08-29Bibliographically approved

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Nilsson Ekdahl, Kristina

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Nilsson, BoTeramura, YujiNilsson Ekdahl, Kristina
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