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Dynamic covalent kinetic resolution
Jiangnan Univ, China.
Hunan Univ, China.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Massachusetts, USA. (Linnaeus Ctr Biomat Chem, BMC;BBCL)ORCID iD: 0000-0002-1533-6514
2020 (English)In: Catalysis reviews. Science and engineering, ISSN 0161-4940, E-ISSN 1520-5703, Vol. 62, no 1, p. 66-95Article in journal (Refereed) Published
Abstract [en]

Implemented with the highly efficient concept of Dynamic Kinetic Resolution (DKR), dynamic covalent chemistry can be a useful strategy for the synthesis of enantioenriched compounds. This gives rise to dynamic covalent kinetic resolution (DCKR), a subset of DKR that over the last decades has emerged as increasingly fruitful, with many applications in asymmetric synthesis and catalysis. All DKR protocols are composed of two important parts: substrate racemization and asymmetric transformation, which can lead to yields of >50% with good enantiomeric excesses (ee) of the products. In DCKR systems, by utilizing reversible covalent reactions as the racemization strategy, the substrate enantiomers can be easily interconverted without the presence of any racemase or transition metal catalyst. Enzymes or other chiral catalysts can then be adopted for the resolution step, leading to products with high enantiopurities. This tutorial review focuses on the development of DCKR systems, based on different reversible reactions, and their applications in asymmetric synthesis.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2020. Vol. 62, no 1, p. 66-95
Keywords [en]
Dynamic kinetic resolution, dynamic covalent chemistry, asymmetric synthesis, organocatalysis, enzymatic catalysis
National Category
Chemical Sciences
Research subject
Natural Science, Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-89312DOI: 10.1080/01614940.2019.1664031ISI: 000486173200001Scopus ID: 2-s2.0-85073775071OAI: oai:DiVA.org:lnu-89312DiVA, id: diva2:1354950
Available from: 2019-09-26 Created: 2019-09-26 Last updated: 2022-03-15Bibliographically approved

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Ramström, Olof

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CiteExportLink to record
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