Rachel Carson’s popular scientific book Silent Spring (1962) occupies a fascinating place in between the science fiction of the atomic era and the eco-horror of the hippie era and hence epitomizes several stages of complex transmediations. Carson borrowed formal and generic ideas from science fiction that she incorporated into her seminal book, merging discourses of science and popular communication. In addition, the eco-horror, or more specifically nature-on-a-rampage, film genre of the 1970s used Silent Spring as inspiration. This chapter is divided into three sections. “Silent Spring Retrospectively” examines how Silent Spring was influenced by the science fiction films of the decade preceding its publication. In “Silent Spring Prospectively,” the nature of the transmediation of both the media content and the form of Silent Spring into the eco-horror film Kingdom of the Spiders is investigated. Finally, “Silent Spring Introspectively” draws some conclusions on the actual consequences of Anthropocene representation, mediation and transmediation. These different analyses are concerned with the transmediation of the scientific discourse of the Anthropocene as a common “source” to three different qualified media products. However, as the chapter argues, there are also transmediations connected within these three mediations from science fiction to popular science to eco-horror. Therefore, in this particular form of intermedial ecocriticism, this inquiry considers both transmediations from one discourse to different media types and transmediations between different media products.