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Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies-Synthesis and Applications
Agr Res Ctr, Egypt;Beni Suef Univ, Egypt.
Agr Res Ctr, Egypt.
Beni Suef Univ, Egypt.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0002-8517-723X
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2019 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 20, no 24, p. 1-21, article id 6304Article, review/survey (Refereed) Published
Abstract [en]

Materials that can mimic the molecular recognition-based functions found in biology are a significant goal for science and technology. Molecular imprinting is a technology that addresses this challenge by providing polymeric materials with antibody-like recognition characteristics. Recently, significant progress has been achieved in solving many of the practical problems traditionally associated with molecularly imprinted polymers (MIPs), such as difficulties with imprinting of proteins, poor compatibility with aqueous environments, template leakage, and the presence of heterogeneous populations of binding sites in the polymers that contribute to high levels of non-specific binding. This success is closely related to the technology-driven shift in MIP research from traditional bulk polymer formats into the nanomaterial domain. The aim of this article is to throw light on recent developments in this field and to present a critical discussion of the current state of molecular imprinting and its potential in real world applications.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 20, no 24, p. 1-21, article id 6304
Keywords [en]
assay, molecular imprinting, nanoMIP, protein imprinting, sensor, therapeutic agent
National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-91809DOI: 10.3390/ijms20246304ISI: 000506840100197PubMedID: 31847152Scopus ID: 2-s2.0-85076856149OAI: oai:DiVA.org:lnu-91809DiVA, id: diva2:1391293
Available from: 2020-02-04 Created: 2020-02-04 Last updated: 2023-01-18Bibliographically approved

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Mahajan, RashmiWiklander, Jesper G.Nicholls, Ian A.

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