Beyond identifying and counting the things that go wrong, understanding how and why they go wrong requires qualitative research, especially for low frequency events. The purpose of this study was to identify and characterize patient safety and quality issues related to health information technology (HIT) in medical imaging by collecting and analyzing incident reports through the lens of thematic analysis. In this article, we analyze 5 clusters: staff related issues (16%), issues withdiagnosis (15%), HIT incidents that involved “paperrecord” (12%), information and communication related(4%), and “action taken” related issues (4%). Human factors involved people failing to scan forms into the computer system (consents, requests, bookings,questionnaires, assessments, treatments andprescriptions), and another 4% involved failure to enter verbally imparted information into the system (aboutinfectious patients, cancelled cases, and the status ofreports). All of these problems had their genesis in human errors and violations. Human factors were found to cause more deleterious effects than technical factors. Of three instances of deaths caused by diagnostic issues, two were triggered by human factors, missed diagnosis. However, “staff or organizational outcome” was evenly distributed for both human and technical factors. It was therefore important to identify and characterize these incidents related to health information technology in medical imaging through the lens of thematic analysis, to providea basis for improvements in preventing issues and improving clinical practice.