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High MHC gene copy number maintains diversity despite homozygosity in a Critically Endangered single-island endemic bird, but no evidence of MHC-based mate choice
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Lund University, Sweden;Univ Oregon, USA.ORCID iD: 0000-0002-6139-7828
Univ Cambridge, UK;Fauna & Flora Int, UK.
Univ Cambridge, UK.ORCID iD: 0000-0002-8426-610X
Univ Cambridge, UK.
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2020 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 29, no 19, p. 3578-3592Article in journal (Refereed) Published
Abstract [en]

Small population sizes can, over time, put species at risk due to the loss of genetic variation and the deleterious effects of inbreeding. Losing diversity in the major histocompatibility complex (MHC) could be particularly harmful, given its key role in the immune system. Here, we assess MHC class I (MHC-I) diversity and its effects on mate choice and survival in the Critically Endangered Raso larkAlauda razae, a species restricted to the 7 km(2)islet of Raso, Cape Verde, since similar to 1460, whose population size has dropped as low as 20 pairs. Exhaustively genotyping 122 individuals, we find no effect of MHC-I genotype/diversity on mate choice or survival. However, we demonstrate that MHC-I diversity has been maintained through extreme bottlenecks by retention of a high number of gene copies (at least 14), aided by cosegregation of multiple haplotypes comprising 2-8 linked MHC-I loci. Within-locus homozygosity is high, contributing to low population-wide diversity. Conversely, each individual had comparably many alleles, 6-16 (average 11), and the large and divergent haplotypes occur at high frequency in the population, resulting in high within-individual MHC-I diversity. This functional immune gene diversity will be of critical importance for this highly threatened species' adaptive potential.

Place, publisher, year, edition, pages
John Wiley & Sons, 2020. Vol. 29, no 19, p. 3578-3592
Keywords [en]
Alauda razae, conservation genetics, immune gene, MHCclass I, population bottleneck, Raso lark
National Category
Ecology
Research subject
Natural Science, Ecology
Identifiers
URN: urn:nbn:se:lnu:diva-97179DOI: 10.1111/mec.15471ISI: 000540541000001PubMedID: 32416000Scopus ID: 2-s2.0-85086518576OAI: oai:DiVA.org:lnu-97179DiVA, id: diva2:1454385
Available from: 2020-07-16 Created: 2020-07-16 Last updated: 2021-05-06Bibliographically approved

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Stervander, MartinThorley, JackWesterdahl, Helena
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