Long term success of eHealth initiatives rests on the cooperation between major parties in society. This paper reports on an ongoing project with the aim of providing support for elderly living longer at home. The general template of Quadruple Helix cooperation aids the formation and execution of projects with broad impact ambitions and could guide the design of solutions for an aging population. A general model for cooperation, based on the different challenges encountered in an ongoing research and development project, is presented and discussed, with regard to a process of the Quadruple Helix type. Key components of the processes include a lifecycle-based process view of the solutions and the technical base, comprising the continuous development of solutions, business models and technical platforms. At the centre of the approach reside user interaction aspects and the desired outcomes of changed behaviours. These rest on the abilities of a technical platform to afford the personalization of solutions fitting the varying needs of elderly living longer at home. As a result, a lifecycle-based and end-user driven co-design process is presented as an example of a Quadruple Helix project organization. The project shows a way of operationalizing Quadruple Helix in software development through the use of co-design concepts.