he latest climate change projections for Sweden suggest mean annual temperature increase of up to 5.5 degrees C by 2100, compared to 1961-1990 levels. In this study we investigate the potential impacts of climate change on the energy demand for space conditioning, overheating risk and indoor thermal comfort of a modern multi-storey residential building in Sweden. We explore climate change adaptation strategies to improve the building's performance under the climate change conditions, including increased ventilation, solar shading, improved windows and mechanical cooling. The building is analysed under future climate projections for the 2050-2059 time frame, with representative concentration pathway (RCP) 2.6, 4.5 and 8.5 scenarios. The building's performances under these future climates are compared to those under the historical climate of 1961-1990 and recent climate of 1981-2010. The results suggest that climate change will significantly influence energy performance and indoor comfort conditions of buildings in the Swedish context. Overheating hours and Predicted Percentage of Dissatisfied (PPD) increased significantly under the future climate scenarios. Furthermore space heating demand is reduced and cooling demand is increased for the studied building. However, effective adaptation strategies significantly improved the buildings' energy and indoor climate performances under both current and future climate conditions.Keywords