lnu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Complement deposition, C4d, on platelets is associated with vascular events in systemic lupus erythematosus
Karolinska University Hospital, Sweden;Karolinska institutet, Sweden.ORCID iD: 0000-0003-3396-3244
Karolinska University Hospital, Sweden;Karolinska institutet, Sweden.
Karolinska University Hospital, Sweden;Karolinska institutet, Sweden.
Karolinska institutet, Sweden.ORCID iD: 0000-0002-9769-324X
Show others and affiliations
2020 (English)In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 59, no 11, p. 3264-3274Article in journal (Refereed) Published
Abstract [en]

Objective. Complement components, including C4d, can be found on activated platelets, a process associated with vascular disease in SLE. We investigated whether platelet C4d (PC4d) adds additional value to traditional and known lupus-associated risk factors when identifying SLE patients with vascular disease. Methods. This cross-sectional study included 308 well-characterized SLE patients and 308 matched general population controls. PC4d deposition was analysed using flow cytometry. Values >95% of controls were considered as PC4d positive (+). aPL were determined by Luminex, and the LA test was performed by DRVVT. History of vascular disease (composite and as separate outcomes) was defined at inclusion. Results. SLE patients had increased PC4d deposition as compared with population controls (50 vs 5%, P < 0.0001). PC4d+ positively associated with any vascular events, and separately with venous and cerebrovascular events, and also with all investigated aPL profiles. The association for any vascular event remained statistically significant after adjustment for traditional and SLE-associated risk factors (odds ratio: 2.3, 95% CI: 1.3, 4.3, P = 0.008). Compared with patients negative for both PC4d and LA, patients with double positivity were more likely to have vascular disease (odds ratio: 12.3, 95% CI: 5.4, 29.3; attributable proportion due to interaction 0.8, 95% CI: 0.4, 1.1) Conclusion. PC4d+ is associated with vascular events in SLE, independently of traditional and SLE-associated risk factors. Concurrent presence of PC4d and LA seem to interact to further increase the odds for vascular events. Prospective studies should examine whether the aPL/PC4d combination can improve prediction of vascular events in SLE and/or APS.

Place, publisher, year, edition, pages
Oxford University Press, 2020. Vol. 59, no 11, p. 3264-3274
Keywords [en]
systemic lupus erythematosus, antiphospholipid syndrome, C4d, vascular events, antibodies, risk factors
National Category
Rheumatology and Autoimmunity
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-100287DOI: 10.1093/rheumatology/keaa092ISI: 000593174200037PubMedID: 32259250Scopus ID: 2-s2.0-85094932112OAI: oai:DiVA.org:lnu-100287DiVA, id: diva2:1520248
Available from: 2021-01-20 Created: 2021-01-20 Last updated: 2021-05-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Nilsson Ekdahl, Kristina

Search in DiVA

By author/editor
Svenungsson, ElisabetRossides, MariosNilsson Ekdahl, Kristina
By organisation
Department of Chemistry and Biomedical Sciences
In the same journal
Rheumatology
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 58 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf