Since COVID-19 affects tourism globally, understanding what influences biosecurity behaviour is essential. However, few theoretically conceptualized studies have been conducted on COVID-19 biosecurity travel behaviour. To fill this gap, this study built and tested a comprehensive research model that includes non-pharmaceutical interventions (NPIs), psychological and financial resilience, and biosecurity behaviour, along with four moderators. Results reveal that NPIs have a great effect on biosecurity behaviour and the four moderators partially differentiate international travel behaviour, suggesting substantial theoretical and practical implications for tourism-related biosecurity practices.