This study focuses on multi-holed orifice plates, which have superior flow measuring characteristics as comparedto their conventional counterparts. However, literature is scant on quantitative parametric investigations. In thisexperimental study, the performance of a multi-holed orifice plate is evaluated for variable number of holes (n),equivalent diameter ratio (EDR), compactness ratio (C), plate thickness ratio (s/d) and upstream developinglength (L/D) in developing flow regimes for the Reynolds number range of 24,500–55,500 by using CentralComposite Design. A total number of 324 experiments were performed. It was found that EDR has the mostsignificant effect on pressure loss coefficient, followed by ‘n’ and ‘C’. Moreover, it was found out that singleorifice (SO) and multi-holed orifice (MO) have almost the same pressure losses for the same value of EDR/β.However, flow develops quickly for MOs. Higher values of coefficient of discharge were observed in the case ofMOs as compared to the SOs with little effect of upstream disturbances. The effect of developing length is significanton the accuracy of orifice meter. However, when the multi-holed orifice plates are installed at 2D upstreamlength, the effect of upstream disturbances are diminished. This result provides the flexibility ofinstallation, which means that multi-holed orifices can be installed at 2D. The experimental data is in goodagreement with literature. Finally, an optimum orifice plate (5,0.4,0.7) was selected for flow developing regionwith minimum pressure loss coefficient based upon the experimental results.