Many social problems in emerging economies and developing countries remain unsolved. This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book introduces social innovation of ventures in emerging economies and developing countries as a relevant concept and a theoretical field. It presents five conceptual and/or empirical contributions that underpin attributes, processes and practices for building social innovation in the Americas. The book introduces the positive deviance approach to the social innovation domain, Victoria Konovalenko Slettli and Arvind Singhal broaden our understanding of processes nurturing distributed and generative problem-solving via cases in the rural Misiones Province of Argentina and in New Hampshire in USA. It relies on the theoretical perspectives of entrepreneurial resourcefulness and bricolage, which are well established within entrepreneurship research, and linking these concepts with the social innovation domain will further stimulate exchange between related scholarly domains.