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Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Harvard Med Sch, USA.
Harvard Med Sch, USA.
Harvard Med Sch, USA.
Univ Oslo, Norway.ORCID iD: 0000-0002-7174-9225
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2021 (English)In: Bioactive Materials, E-ISSN 2452-199X, Vol. 6, no 11, p. 3947-3961Article in journal (Refereed) Published
Abstract [en]

Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor, utilizing epoxide ring-opening reactions and visible light-crosslinking. This chemical modification allows the obtaining of an elastic protein-based hydrogel (GELGYM) with excellent biomimetic properties, approaching those of the native tissue. GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80% compared to Gelatin-methacryloyl (GeIMA), the most studied derivative of gelatin used as a bioadhesive. GELGYM is also highly biocompatible and supports cellular adhesion, proliferation, and migration in both 2 and 3-dimensional cell-cultures. These characteristics along with its super adhesion to biological tissues such as cornea, aorta, heart, muscle, kidney, liver, and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation, tissue adhesive, wound dressing, bioprinting, and drug and cell delivery.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 6, no 11, p. 3947-3961
Keywords [en]
Natural-based hydrogel, Gelatin, Biocompatible, Biomimetic, Bioadhesive, Cornea
National Category
Biomaterials Science
Research subject
Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-106794DOI: 10.1016/j.bioactmat.2021.03.042ISI: 000685107200021PubMedID: 33937594Scopus ID: 2-s2.0-85104362928Local ID: 2021OAI: oai:DiVA.org:lnu-106794DiVA, id: diva2:1590794
Available from: 2021-09-03 Created: 2021-09-03 Last updated: 2023-01-24Bibliographically approved

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Nilsson, Per H.

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Islam, RakibulReyes-Ortega, FelisaAlba-Molina, DavidNilsson, Per H.
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