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Improved Solvothermal Synthesis of gamma-Fe2O3 Magnetic Nanoparticles for SiO2 Coating
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0002-8517-723X
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (Linnaeus Ctr Biomat Chem, BMC;BBCL)ORCID iD: 0000-0002-3921-4204
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Linnaeus University, Linnaeus Knowledge Environments, Advanced Materials. (Linnaeus Ctr Biomat Chem, BMC;BBCL)ORCID iD: 0000-0002-0407-6542
2021 (English)In: Nanomaterials, E-ISSN 2079-4991, Vol. 11, no 8, article id 1889Article in journal (Refereed) Published
Abstract [en]

Monodisperse magnetic gamma-Fe2O3 nanoparticles (MNPs) were prepared by a simple, improved, one-pot solvothermal synthesis using SDS and PEG 6000 as double capping reagents. This double protecting layer afforded better MNP uniformity (Z average 257 +/- 11.12 nm, PDI = 0.18) and colloidal stability. Materials were characterized by DLS, SEM, TEM, XPS, and XRD. The use of these MNPs in the synthesis of core-shell structures with uniform and tunable silica coatings was demonstrated, as silica coated MNPs are important for use in a range of applications, including magnetic separation and catalysis and as platforms for templated nanogel synthesis.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 11, no 8, article id 1889
Keywords [en]
co-precipitation, core-shell nanoparticle, iron-oxide, magnetic nanoparticle, silica coated magnetic nanoparticle, solvothermal, surfactant
National Category
Physical Chemistry Materials Chemistry
Research subject
Chemistry, Physical Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-106870DOI: 10.3390/nano11081889ISI: 000689952200001PubMedID: 34443719Scopus ID: 2-s2.0-85110623305Local ID: 2021OAI: oai:DiVA.org:lnu-106870DiVA, id: diva2:1592866
Available from: 2021-09-09 Created: 2021-09-09 Last updated: 2023-01-18Bibliographically approved
In thesis
1. Strategies for developing peptide and protein selective plastic antibodies
Open this publication in new window or tab >>Strategies for developing peptide and protein selective plastic antibodies
2022 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The objective of the thesis was to explore approaches for the development of molecularly imprinted materials with predetermined selectivity for peptide or protein targets. In particular, the work has focused on molecularly imprinted nanoparticles synthesized using solid-phase synthesis protocols. Initially, previously developed glass bead-based protocols were used to prepare imprinted nanoparticles selective for neuropeptide oxytocin (Paper I), with quartz crystal microbalance (QCM) studies revealed affinity for the peptide comparable to those of commercial antibodies. In an effort to improve nanoparticle yield and to simplify aspects of nanoparticle production, a novel magnetic nanoparticle-based synthesis and separation strategy was investigated (Paper II). Using proteins pepsin and trypsin as templates, fluorescent nanoparticles were synthesized, and were shown to have picomolar affinities for their respective templates in a fluorescence-based assay format. To further develop this novel approach to imprinted nanoparticle synthesis, improvements in both the synthesis of the iron oxide core and the silica-coating of the magnetic nanoparticles were established (Paper III). Collectively, these studies have provided improved methods for the synthesis and characterization of synthetic polymer nanoparticles with antibody-like affinities for peptide and protein targets and should prove useful in the future development of plastic antibodies for diagnostic applications.

Place, publisher, year, edition, pages
Linnaeus University Press, 2022. p. 77
Series
Linnaeus University Dissertations ; 443
Keywords
Competitive assays, molecularly imprinted polymer, magnetic nanoparticle, nanogel, nanoparticle, plastic antibody, solid-phase synthesis, QCM.
National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Biochemistry
Identifiers
urn:nbn:se:lnu:diva-110961 (URN)9789189460775 (ISBN)9789189460782 (ISBN)
Public defence
2022-04-08, Azur salen, Hus Vita, Kalmar, 09:30 (English)
Opponent
Supervisors
Available from: 2022-03-24 Created: 2022-03-24 Last updated: 2024-03-11Bibliographically approved

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Mahajan, RashmiSuriyanarayanan, SubramanianNicholls, Ian A.

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