The Middle East and Sorth Africa (MENA) is a large, complex, and diverse region and is viewed as a huge centre of cultural and travel influence. Nevertheless, the region has been plagued by geopolitical tensions, political turmoil, instability, and conflict over the decades. The conflict-ridden and controversial image of the region in many tourism-generating markets has negatively affected the flow of tourists to the region and hindered the development of tourism despite its wealth of cultural heritage endowments, a climate conducive to tourism, and leisure resources. More recently, in the aftermath of the ‘Arab Spring’ and the advent of Islamic extremism and fundamentalism, cultural heritage in parts of the region has been placed at risk and has witnessed large-scale devastation, destruction, and looting. The latter has stressed the urgency for post-conflict reconstruction in the Middle East context. The introductory chapter provides an introduction and background to the MENA region from a geographical and historical perspective in general and the cultural and heritage tourism in the region in particular and the challenges it faces. It will also outline the development of tourism in the MENA region and identify key issues in the region with links to the chapters in the book. © 2021 selection and editorial matter, C. Michael Hall and Siamak Seyfi.