Sustainability, digitalization, demographic change, and health are some of the most important megatrends in the tourism sector. The contributions in this chapter, therefore, focus on their relevance in the context of luxury travel. Four authors have their say, based on their many years of practical experience in the various fields, who can give a profound account of the specific characteristics of these megatrends and why they are relevant. Stefan Gössling concisely describes from a human ecological perspective whether luxury tourism is compatible with the sustainable use of resources and ecosystems. Marc Aeberhard discusses in his contribution whether the immaterial part of the phenomenon of luxury is compatible with the demands for more and more digitalization. Jörg Meurer vividly demonstrates how demographic change is creating new target groups for luxury and premium brands and how these target groups are gaining a completely new and exciting relevance. Finally, Mario Krause places the aspect of health as an immaterial factor in relation to luxury (and travel), setting an important accent as a counterpoint to the ubiquitous phenomenon of wellness.