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Stable CAAC-based Ruthenium Complexes for Dynamic Olefin Metathesis Under Mild Conditions
KTH Royal Institute of Technology, Sweden.ORCID iD: 0000-0002-9001-7708
KTH Royal Institute of Technology, Sweden.
Stockholm University, Sweden.ORCID iD: 0000-0001-9118-1342
KTH Royal Institute of Technology, Sweden.
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2021 (English)In: ChemCatChem, ISSN 1867-3880, E-ISSN 1867-3899, Vol. 13, no 22, p. 4841-4847Article in journal (Refereed) Published
Abstract [en]

A series of olefin metathesis catalysts bearing cyclic (alkyl)(amino)carbene (CAAC) ligands of varying size and steric demand has been synthesized and evaluated in ring-closing-, self-, and cross-metathesis reactions at room temperature. The catalysts were also probed for potential applications in dynamic covalent chemistry. The majority of the catalysts showed high stability, and remained active in the reaction mixtures for several days, including in methanol-based solutions. Higher temperatures could be used to control the reactivity towards sterically challenging substrates, enabling formation of tetrasubstituted olefins. The CAAC complexes exhibited remarkable functional group tolerance towards heteroaromatic and nucleophilic additives, making them potentially useful in the screening of biologically active compounds.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 13, no 22, p. 4841-4847
Keywords [en]
Dynamic chemistry, Metathesis, Catalysis, Carbene, Exchange
National Category
Organic Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-108107DOI: 10.1002/cctc.202101172ISI: 000705573300001Scopus ID: 2-s2.0-85116780878Local ID: 2021OAI: oai:DiVA.org:lnu-108107DiVA, id: diva2:1612921
Available from: 2021-11-19 Created: 2021-11-19 Last updated: 2022-03-15Bibliographically approved

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Ramström, Olof

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