We advocate a novel concept of dependable intelligent edge systems (DIES) i.e., the edge systems ensuring a high degree of dependability (e.g., security, safety, and robustness) and autonomy because of their applications in critical domains. Building DIES entail a paradigm shift in architectures for acquiring, storing, and processing potentially large amounts of complex data: data management is placed at the edge between the data sources and local processing entities, with loose coupling to storage and processing services located in the cloud. As such, the literal definition of edge and intelligence is adopted, i.e., the ability to acquire and apply knowledge and skills is shifted towards the edge of the network, outside the cloud infrastructure. This paradigm shift offers flexibility, auto configuration, and auto diagnosis, but also introduces novel challenges. © 2019 ACM.