Modern software systems often have to cope with uncertain operation conditions, such as changing workloads or fluctuating interference in a wireless network. To ensure that these systems meet their goals these uncertainties have to be mitigated. One approach to realize this is self-adaptation that equips a system with a feedback loop. The feedback loop implements four core functions - monitor, analyze, plan, and execute - that share knowledge in the form of runtime models. For systems with a large number of adaptation options, i.e., large adaptation spaces, deciding which option to select for adaptation may be time consuming or even infeasible within the available time window to make an adaptation decision. This is particularly the case when rigorous analysis techniques are used to select adaptation options, such as formal verification at runtime, which is widely adopted. One technique to deal with the analysis of a large number of adaptation options is reducing the adaptation space using machine learning. State of the art has showed the effectiveness of this technique, yet, a systematic solution that is able to handle different types of goals is lacking. In this paper, we present ML2ASR+, short for Machine Learning to Adaptation Space Reduction Plus. Central to ML2ASR+ is a configurable machine learning pipeline that supports effective analysis of large adaptation spaces for threshold, optimization, and setpoint goals. We evaluate ML2ASR+ for two applications with different sizes of adaptation spaces: an Internet-of-Things application and a service-based system. The results demonstrate that ML2ASR+ can be applied to deal with different types of goals and is able to reduce the adaptation space and hence the time to make adaptation decisions with over 90%, with negligible effect on the realization of the adaptation goals. (C) 2022 The Authors. Published by Elsevier Inc.