Although active transport contributes to environmental and human health, only limited research has been conducted on what makes people participate in active transport in tourism-related contexts. To fill this gap, research was conducted on theoretically conceptualized relationships between pro-social behavior on active transport, air quality, climate change mitigation, and health with a moderator of leisure and tourism activity. In order to collect data, an online survey was conducted targeting Korean cyclists and walkers, and PLS-SEM and deep learning were applied for data analysis. Results revealed that pro-social behavior on active transport has a great effect on perceived air quality. Health is strongly influenced by pursuing climate change mitigation and a strong impact of active transport on health was identified. There were greater effects between pro-social behavior and air quality as well as pro-social behavior and climate change mitigation for those engaged in active transport for tourism than for leisure, while the leisure group has a stronger relationship between pro-social behavior and health than for tourism. The results are valuable for encouraging active transport behavior.