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A cell glue: Inducing cell adhesion using surface modification with cell-penetrating peptide-peg-lipid for 3d cell structures
University of Tokyo, Japan;Uppsala University, Sweden.
Uppsala University, Sweden.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Linnaeus University, Linnaeus Knowledge Environments, Advanced Materials. Uppsala University, Sweden. (Linnaeus Ctr Biomat Chem, BMC)ORCID iD: 0000-0001-7888-1571
Uppsala University Hospital, Sweden.
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2019 (English)In: The Pinnacle of Biomaterials Innovationand Excellence: Transactions of the 42nd Annual Meeting Volume XL, Part 1, Society for Biomaterials , 2019, Vol. 40, no 1, p. 678-Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Statement of Purpose: The ultimate goal of regenerative therapy is the transplantation of functional stem cells-derived tissues and organs to replace those lost as the result of pathology or tissue damage. Since tissues and organs are complicated 3D structures, 3D scaffolds such as decellularized organs and tissues, are required to properly orient living functional cells of different types. 3D scaffolds offer an environment for cell adhesion that differs from that of conventional 2D culture. Therefore, the induction and control of cell attachment, not only to 2D substrate surfaces but also to 3D scaffolds, is of great importance. Here, we propose new type of cell glue made of cell-penetrating peptides (CPP) and PEG-conjugated lipid, which are used for cell-surface modification. PEG-lipid derivatives are incorporated into the lipid bilayer membranes of cells via hydrophobic interactions, and the CPP anchored onto the cell membrane could work as an adhesive domain. In our study, various floating cells, (i.e., T cells, B cells) were used to examine the adhesive efficacy by cell surface modification with CPP-PEG-lipid onto material surface as well as PS microfiber-based 3D scaffolds.

Place, publisher, year, edition, pages
Society for Biomaterials , 2019. Vol. 40, no 1, p. 678-
Series
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, ISSN 1526-7547 ; 40
Keywords [en]
cell surface modification, poly(ethylene glycol)-conjugated phospholipid (PEG-lipid), cell-penetrating peptide (CPP), cell adhesion, 3D structure
National Category
Biochemistry and Molecular Biology
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-117597Scopus ID: 2-s2.0-85065398538ISBN: 9781510883901 (print)OAI: oai:DiVA.org:lnu-117597DiVA, id: diva2:1711748
Conference
Society for Biomaterials 42nd Annual Meeting, Seattle, Washington, USA 3 - 6 April 2019
Available from: 2022-11-18 Created: 2022-11-18 Last updated: 2023-01-24Bibliographically approved

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Nilsson Ekdahl, Kristina

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